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阮晴

所在单位：物理与天文学院

学历：博士毕业

学位：博士

职称：讲师

学科：核科学与技术

同专业硕导

教育背景
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1
2016.09 - 2019.06

北京师范大学一化学一硕士毕业一硕士
2
2019.09 - 2022.06

北京师范大学一药物化学与分子工程一博士毕业一博士
3
2012.09 - 2016.06

南京师范大学一化学一大学毕业一学士

教育教学
Teacher homepage

授课信息（近三年）

大学生学术实践, 春学期, 2024-2025, 本科生课程

学生信息

硕士

倪佳茹

科学研究
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论文成果

[1]Ruan, Qing; Ding, Dajie; Diao, Lina; Feng, Junhong; Yin, Guangxing; Jiang, Yuhao; Wang, Qianna; Han, Peiwen; Jiang, Jianyong; Zhang, Junbo| Synthesis and Preclinical Evaluation of Novel <SUP>99m</SUP>Tc-Labeled FAPI-46 Derivatives with Significant Tumor Uptake and Improved Tumor-to-Nontarget Ratios, JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (4) :3190-3202
[2]Ruan, Qing; Wang, Qianna; Jiang, Yuhao; Feng, Junhong; Yin, Guangxing; Zhang, Junbo| Synthesis and Evaluation of 99mTc-Labeled FAP Inhibitors with Different Linkers for Imaging of Fibroblast Activation Proteins in Tumors, JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (7) :4952-4960
[3]Ruan, Qing; Diao, Lina; Li, Zuojie; Ding, Dajie; Han, Peiwen; Jiang, Yuhao; Yin, Guangxing; Feng, Junhong; Wang, Qianna; Jiang, Jianyong; Zhang, Junbo| Design and preclinical evaluation of 99mTc-Labeled dimer FAPI-46 derivatives as potential tumor radiotracers, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 287
[4]Ruan, Qing; Jiang, Yuhao; Li, Zuojie; Duan, Xiaojiang; Diao, Lina; Ding, Dajie; Han, Peiwen; Yin, Guangxing; Jiang, Jianyong; Zhang, Junbo| [68Ga]Ga-PG2-2FAPI: A DPro-Gly-Modified Dimeric FAPI Probe with Enhanced Tumor Uptake and Retention, MOLECULAR PHARMACEUTICS, 2026, 23 (3) :2097-2107
[5]Ruan, Qing; Diao, Lina; Ding, Dajie; Han, Peiwen; Yin, Guangxing; Jiang, Yuhao; Zhang, Junbo| Synthesis and Evaluation of Novel 99mTc-Labeled Fibroblast Activation Protein Inhibitors Containing Cyclohexane as Promising Tumor Tracers, MOLECULAR PHARMACEUTICS, 2025, 22 (11) :7121-7131
[6]Ruan, Qing; Liu, Yitong; Liao, Lihao; Hao, Jinyu; Jiang, Yuhao; Jiang, Jianyong; Zhang, Junbo| Synthesis and Evaluation of <SUP>99m</SUP>Tc-Labelled 2-Nitroimidazole Derivatives with Different Linkers for Tumour Hypoxia Imaging, PHARMACEUTICALS, 2023, 16 (9)
[7]Li, Zuojie; Ruan, Qing; Jiang, Yuhao; Wang, Qianna; Yin, Guangxing; Feng, Junhong; Zhang, Junbo| Current Status and Perspectives of Novel Radiopharmaceuticals with Heterologous Dual-targeted Functions: 2013-2023, JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (24) :21644-2167
[8]Yin, Guangxing; Ruan, Qing; Ding, Dajie; Jiang, Yuhao; Han, Peiwen; Xiao, Qingna; Chen, Xiaoliang; Zhang, Junbo| Preparation of a Kit Formulation of [<SUP>99m</SUP>Tc]Tc-CN7DM, a Mannose Derivative for Tumor Imaging, and an Exploratory Human Study, MOLECULAR PHARMACEUTICS, 2025, 22 (7) :4214-4220
[9]Li, Zuojie; Jiang, Yuhao; Ruan, Qing; Yin, Guangxing; Han, Peiwen; Duan, Xiaojiang; Zhang, Junbo| Synthesis and Evaluation of <SUP>99m</SUP>Tc-Labeled <sub>D</sub>Pro-Gly-Containing Tracers Targeting PSMA, MOLECULAR PHARMACEUTICS, 2024, 21 (10) :5305-5314
[10]Deng, Ruotong; Chen, Wei; Zhu, Hanjie; Li, Yuxi; Ou, Yining; Wang, Jian; Ruan, Qing; Zhang, Xuanying; Zhang, Junbo; Zhang, Yongxian; Niu, Yantao; Hu, Zhubin; Zhang, Chunlei; Xu, Huaping; Cao, Wei| Molecular engineering of melanin for enhanced biological γ-ray protection, NATURE COMMUNICATIONS, 2025, 16 (1)
[11]Yin, Guangxing; Jiang, Yuhao; Feng, Junhong; Ruan, Qing; Wang, Qianna; Han, Peiwen; Zhang, Junbo| Influence of Linker Molecules on the Biodistribution Characteristics of <SUP>99m</SUP>Tc-labeled Mannose Derivatives with an Isocyanide-Coordinated Group, ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2025, 8 (2) :566-577
[12]Jiang, Yuhao; Yin, Guangxing; Li, Zuojie; Han, Peiwen; Wang, Qianna; Feng, Junhong; Ruan, Qing; Ding, Dajie; Jiang, Jianyong; Zhang, Junbo| Synthesis and bioevaluation of novel 99mTc-labelled ferrioxamine B isonitrile complexes as potential bacterial infection imaging agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 304
[13]Han, Peiwen; Jiang, Yuhao; Ruan, Qing; Yin, Guangxing; Wang, Qianna; Feng, Junhong; Ding, Dajie; Xiao, Qingna; Li, Zuojie; Zhang, Junbo| Advances in radiolabelled CDK4/6 inhibitors for in vivo imaging of CDK4/6 activity in tumours, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 303
[14]Jiang, Yuhao; Wang, Qianna; Duan, Xiaojiang; Feng, Junhong; Yin, Guangxing; Han, Peiwen; Ruan, Qing; Zhao, Ziqing; Jiang, Jianyong; Zhang, Junbo| Synthesis and Biological Evaluation of a Novel 68Ga-Labeled Ubiquicidin 29-41 Complex for PET Imaging of Bacterial Infections, MOLECULAR PHARMACEUTICS, 2025, 22 (11) :6980-6988
[15]Jiang, Yuhao; Wang, Qianna; Feng, Junhong; Yin, Guangxing; Han, Peiwen; Ruan, Qing; Zhang, Junbo| A novel Al18F-labelled NOTA-modified ubiquicidin 29-41 derivative as a bacterial infection PET imaging agent, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 289
[16]Han, Peiwen; Jiang, Yuhao; Ruan, Qing; Feng, Junhong; Wang, Qianna; Yin, Guangxing; Li, Zuojie; Xiao, Qingna; Ding, Dajie; Zhang, Junbo| Novel technetium-99m-labelled ribociclib isocyanide derivatives for imaging cyclin-dependent kinase 4/6 (CDK4/6) expression in cancer, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 286
[17]Jiang, Yuhao; Wang, Qianna; Yin, Guangxing; Feng, Junhong; Ruan, Qing; Han, Peiwen; Zhang, Junbo| Development of Novel <SUP>99m</SUP>Tc-Labeled Hydrazinoicotinamide-Modified Ubiquicidin 29-41 Complexes with Improved Target-to-Nontarget Ratios for Bacterial Infection Imaging, ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2025, 8 (2) :470-483
[18]Wang, Qianna; Feng, Junhong; Jiang, Yuhao; Ruan, Qing; Yin, Guangxing; Han, Peiwen; Zhang, Junbo| Development of <SUP>99m</SUP>Tc-Labeled Complexes with a Niraparib HYNIC Derivative for PARP-Positive Tumor Imaging, MOLECULAR PHARMACEUTICS, 2025, 22 (2) :1010-1019
[19]Wang, Qianna; Li, Zuojie; Jiang, Yuhao; Feng, Junhong; Ruan, Qing; Yin, Guangxing; Han, Peiwen; Zhang, Junbo| Synthesis and bioevaluation of a new <SUP>68</SUP>Ga-labelled niraparib derivative that targets PARP-1 for tumour imaging, BIOORGANIC CHEMISTRY, 2025, 154
[20]Li, Zuojie; Duan, Xiaojiang; Han, Peiwen; Yin, Guangxing; Jiang, Yuhao; Ruan, Qing; Zhang, Junbo| Synthesis and Evaluation of <SUP>99m</SUP>Tc-Labeled <sc>l</sc>-Aspartic Acid as a EuK Polymer Linker for Targeting PSMA to a Novel SPECT Tumor Tracer, JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (23) :21617-2162
[21]Feng, Junhong; Zhang, Xuran; Jiang, Yuhao; Wang, Qianna; Ruan, Qing; Yin, Guangxing; Han, Penwen; Du, Jin; Zhang, Junbo| Development of a Novel <SUP>99m</SUP>Tc-Labeled Folate Derivative Containing Phenyl Isonitrile to Target Folate Receptor with Reduced Renal Uptake, MOLECULAR PHARMACEUTICS, 2024, 21 (11) :5681-5689
[22]Wang, Qianna; Feng, Junhong; Jiang, Yuhao; Zhou, Hang; Ruan, Qing; Yin, Guangxing; Zhang, Junbo| Preparation and Evaluation of a Novel <SUP>99m</SUP>Tc-Labeled Niraparib Isonitrile Complex as a Potential PARP-1 Imaging Agent, MOLECULAR PHARMACEUTICS, 2024, 21 (7) :3321-3329
[23]Jiang, Yuhao; Han, Peiwen; Yin, Guangxing; Wang, Qianna; Feng, Junhong; Ruan, Qing; Xiao, Di; Zhang, Junbo| Radiosynthesis and Bioevaluation of <SUP>99m</SUP>Tc-Labeled Isocyanide Ubiquicidin 29-41 Derivatives as Potential Agents for Bacterial Infection Imaging, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (2)
[24]Feng, Junhong; Zhang, Xuran; Jiang, Yuhao; Ruan, Qing; Wang, Qianna; Zhang, Junbo| Preparation and Bioevaluation of a Novel Tc-99m-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent, PHARMACEUTICALS, 2023, 16 (4)
[25]王成栋;杜进;阮晴;张俊波| 靶向肿瘤乏氧的硝基咪唑类放射性药物的研究现状及展望, 肿瘤影像学, 2024, v.33;No.13 (04) :342-354

科研项目

1、交叉课题-江建勇+张俊波(项目名称:具身智能PET与靶向探针的药械协同研究), 2026
2、靶向FAP和线粒体的99mTc和68Ga标记异二聚体配合物用作肿瘤分子探针的研究, 2025

专利成果

1、张俊波;阮晴;江雨豪, 一种含D-脯氨酸甘氨酸多肽修饰的双FAPI衍生物及其应用
2、张俊波;阮晴;丁大杰;冯俊红;江雨豪, 一种含肼基尼古酰胺基的FAPI-46衍生物及其应用
3、张俊波;阮晴;丁大杰;尹广星;韩沛雯, 锝-99m标记含双药效基团的FAPI衍生物及制备方法和应用
4、张俊波;阮晴;王倩娜;江雨豪;冯俊红;王学斌;唐志刚;张站斌;陆洁, 锝-99m标记含D-脯氨酸甘氨酸多肽修饰的FAPI衍生物及制备方法和应用
5、张俊波;阮晴;王倩娜;江雨豪;冯俊红;王学斌;唐志刚;陆洁;张站斌, 锝-99m标记含D-脯氨酸修饰的FAPI衍生物及制备方法和应用
6、张俊波;阮晴;王倩娜, 锝-99m标记含异腈的氨基酸衍生物及制备方法和应用
7、张俊波;王成栋;阮晴, 一种D-脯氨酸修饰的2-硝基咪唑衍生物及制备方法和应用
8、张俊波;李作杰;阮晴;江雨豪, 一种含寡肽链-DPro-Gly修饰的谷氨酸-脲衍生物及其应用
9、张俊波;尹广星;阮晴;江雨豪, 一种含(D)-α-亚氨基酸修饰的甘露糖衍生物及其应用
10、张俊波;尹广星;阮晴;江雨豪;冯俊红;王倩娜, 一种含L-脯氨酸修饰的葡萄糖衍生物及其应用
11、张俊波;李作杰;阮晴;江雨豪, 一种含L-天冬氨酸连接体的谷氨酸-脲二聚体衍生物及其应用
12、张俊波;李作杰;江雨豪;阮晴, 一种含L-脯氨酸的谷氨酸-脲二聚体衍生物及其应用
13、张俊波;冯俊红;阮晴;王倩娜;江雨豪;王学斌;唐志刚;陆洁;张站斌, 锝-99m标记含D-脯氨酸修饰的叶酸衍生物及制备方法和应用
14、张俊波;丁大杰;冯俊红;阮晴;江雨豪, 一种HYNIC修饰的4-(2-氨乙基)苯磺酰胺衍生物及其应用
15、张俊波;江雨豪;王倩娜;冯俊红;尹广星;阮晴;韩沛雯, 一种Al～(18)F标记的抗菌肽UBI 29-41衍生物及制备方法和应用
16、张俊波;韩沛雯;徐晓茜;江雨豪;阮晴;尹广星;李作杰;丁大杰;肖青娜;刁丽娜;钱钰, 一种含L-脯氨酸衍生物的谷氨酸-脲基-赖氨酸类化合物及其制备方法与应用
17、张俊波;江雨豪;冯俊红;阮晴;王学斌;唐志刚;陆洁;张站斌, 一种锝-99m标记含异腈的UBI 29-41衍生物及制备方法和应用
18、张俊波;王倩娜;江雨豪;冯俊红;阮晴, 一种含DOTA修饰的尼拉帕尼衍生物及其应用