研究领域：
机械力（Mechanical force）是能够改变物体位置和形状的一种物理量，它不仅推动宏观世界中的物质运动，也在细胞以及分子层面深刻影响生命活动。近年来的研究已经证实，所有的活细胞都在时刻产生和感受机械力。活细胞产生的机械力为细胞运动、细胞分裂、细胞器生成和运输等基础细胞活动提供动力。同时，细胞也通过感受环境中的机械力信号来调整其形态、代谢水平和基因表达谱，进而对细胞的增殖、凋亡和分化等行为产生重要影响。在发育过程中，化学信号和机械力信号共同参与组织形态建成。在器官层面，多种疾病的发生和发展过程都伴随着细胞或细胞外基质的机械强度的变化，如肝硬化，肺纤维化，动脉粥样硬化等。研究活细胞中机械力信号的产生、传递和调控机制，是目前细胞生物学的前沿科学问题之一。本课题组所开发的新型机械力传感器为在活细胞内机械力信号的研究提供了前所未有的工具。
研究方向：
•活细胞内机械力的检测和相关信号通路研究；
•高通量机械力测量和筛选，即机械力组学（Mechanomics）；
•将活细胞内外的机械力信号重编程为化学和遗传信号来影响细胞行为，实现人工机械力信号转导（Synthetic mechanotransduction）
主要学术论文：
1. Ren Y, Fernandez R, Saito T, Fujita B, Mousavi I, Berro J. Fast Fission Yeast Genome Editing by CRISPR/Cas9 Using Gap Repair and Fluoride Selection. Schizosaccharomyces pombe: Methods and Protocols 2024 Nov 12 (pp. 141-154). New York, NY: Springer US.
2. Ren Y#, Yang J, Fujita B, Zhang Y, Berro J#. Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis. Cell reports. 2024 Sep 24;43(9).
3. Ren Y, Yang J, Fujita B, Jin H, Zhang Y, Berro J. Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors. Science Advances. 2023 Oct 13;9(41):eadi1535.
4. Ren Y#, Lin Q, Berro J#. 2A peptide from ERBV-1 efficiently separates endogenous protein domains in the fission yeast Schizosaccharomyces pombe. microPublication Biology. 2023. 10.17912/micropub.biology.000941.
5. Ren Y#, Berro J#. Isolated THATCH domain of End4 is unable to bind F-actin independently in the fission yeast Schizosaccharomyces pombe. microPublication Biology. 2022. 10.17912/micropub.biology.000508.
6. Lemière J*, Ren Y*, Berro J. Rapid adaptation of endocytosis, exocytosis and eisosomes after an acute increase in membrane tension in yeast cells. Elife. 2021 May 13;10:e62084.
7. Ren Y, He Y, Brown S, Zbornik E, Mlodzianoski MJ, Ma D, Huang F, Mattoo S, Suter DM. A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones. Molecular biology of the cell. 2019 Jul 15;30(15):1817-33. (Cover story)
8. Ren Y, Mlodzianoski MJ, Lee AC, Huang F, Suter DM. A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D. Journal of neural engineering. 2018 Feb 27;15(3):035001.
9. Ren Y, Suter DM. Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate. Neural plasticity. 2016 May 4; 2016.
# 共同通讯；* 相同贡献
专利：
"Coiled-coil Peptides for Force-dependent Applications. " US patent application filed 06/30/2023. Inventors: Julien Berro, Yuan Ren, Yongli Zhang.